Little is known of Karie as she is part of an inactive household. She is a glamorous and attractive Sim and a good friend of her cousin Lindy, to whom she is quite similar. It can be assumed that she shares a weak relationship with her father as a result of his affair.
In Part 14 of Season 2, Karie is first seen at her Aunt Penelope's daycare, where she first meets her cousin Lindy; they play with the dollhouse together and seem to get along well, despite Karie being only a Toddler and Lindy a Child. Lindy and Karie hug each other before she goes home.
Karie and Lindy normally hung out together in their Teen years. Lifesimmer commented that she liked Karie's appearance and that she didn't seem out of place alongside the attractive Santiago family.
Karie graduated in Part 45, at the same time as her cousin, Aiden. Karie is next seen at her house, when Penelope goes to visit, reacting disgustedly to her father's affair with an Imaginary Friend. She is a Mermaid as of the season finale.
Season 3Karie features in the Maple Cove teaser. She then returns in Season 3, still a Mermaid. She now has pink hair and an outrageous dress sense. LifeSimmer said she was following her mother's footsteps: being somewhat snobby and a primadonnna. However, she is still much nicer than Tori and gets along well with the Santiago family.
- Karie is naturally dark-haired.